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Drawbacks of compounds such as those with high cytotoxicity, low specicity, and low stability all have to be considered when selecting an antiepigenetic compound promoting antitumor activity. Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Histone methylation versus histone acetylation: Identication of tumour- specic epigenetic events in medulloblastoma Requip by hypermethylation proling. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.

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